Yes, it is possible to build a tolerance to Cenforce 100 (which contains sildenafil citrate, the same active ingredient as Viagra) over time. While not everyone experiences this, some men may find the medication becomes less effective after prolonged use. This can occur due to physiological changes, worsening underlying conditions such as diabetes or cardiovascular disease, or psychological factors like performance anxiety. In some cases, the body may adapt to the drug, requiring higher doses to achieve the same effect, though increasing dosage should only be done under medical supervision. It's also important to consider lifestyle changes and addressing any underlying health issues to maintain the drug's effectiveness.